CD36, a scavenger receptor implicated in atherosclerosis
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چکیده
منابع مشابه
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism.
CD36, identified more than a quarter of a century ago as a platelet integral membrane glycoprotein (glycoprotein IV), was until recently best known as a receptor for thrombospondin-1 (TSP-1). TSP-1 is found in ECMs and platelet α granules, and it participates in cell attachment, motility, and proliferation, as well as in modulation of protease activity, TGF-β activation, neurite outgrowth, and ...
متن کاملScavenger receptor A and CD36 are implicated in mediating platelet activation induced by oxidized low- density lipoproteins.
See ATVB 2007;2476–2483. CD36, previously known as GPIIIb or GPIV, is an 88-kDa membrane glycoprotein that was isolated from blood platelets soon after being identified on monocytes by monoclonal antibody OKM5. Cloning the CD36 gene showed this cell adhesion molecule to be a member of the scavenger receptor class B family. Moreover, it was observed that CD36 has the capacity to bind oxidized lo...
متن کاملMacrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis.
In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes. These monocytes enter the vessel wall, differentiate into macrophages, and subject the modified lipoproteins to endocytosis throu...
متن کاملCD36: promotion from scavenger receptor to mediator of migration?
As the migration of circulating monocytes into the arterial intima and their subsequent differentiation into fat-laden foam cells are critical events in the development of atherosclerosis, the molecular mechanisms underpinning these two events have been the focus of much study in recent years. In particular, since the seminal studies of Goldstein et al. revealed almost 30 years ago that foam ce...
متن کاملTGF-beta1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages.
Transforming growth factor-beta1 (TGF-beta1), a key cytokine for control of cell growth, extracellular matrix formation, and inflammation control, is secreted by many cells present in the arteriosclerotic plaque. Lipid accumulation in the vessel wall is regarded as an early step in atherogenesis and depends on uptake of modified low-density lipoprotein (LDL) by macrophages through scavenger rec...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2014
ISSN: 2092-6413
DOI: 10.1038/emm.2014.38